| 摘要 |
The present invention relates to a method of synthesizing a 2-substituted nitrogen containing compound having formula (I), by reacting a hydroxylamine of formula (II); or a nitrone of formula (III); with a compound of formula (IV); thereby to form an intermediate compound, and thereafter causing or allowing said intermediate compound to undergo a pericyclic sigmatropic rearrangement reaction to form the compound (I); wherein X is a nucleofugal group, Y is selected from O, S, NH, NR5 and CR6R7, R1 is a group which directs the reactivity of compound (II) on to the oxygen atom and R2 to R9 are each a substituted or unsubstituted aliphatic, aromatic, heteroaryl or cyclic group or hydrogen which is substantially inert or is protected during the reaction. |
