发明名称 18,19-DINOR-VITAMIN D COMPOUNDS
摘要 18,19-dinor-vitamin D3 analogs in which the angular methyl group attached to carbon 13 of the CD-ring and the exocyclic methylene group attached to carbon 10 of the A-ring have been removed and replaced by a hydrogen atom. The 18,19dinor vitamin D compounds are characterized by relatively high cell differentiation activity, and marked intestinal calcium transport activity while exhibiting lower activity than 1.alpha.,25-dihydroxyvitamin D3 in their ability to mobilize calcium from bone. These compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis, because of their preferential calcemic activity, and for the treatment of psoriasis due to their cell differentiation activity.
申请公布号 CA2206876(A1) 申请公布日期 1996.05.30
申请号 CA19952206876 申请日期 1995.11.13
申请人 WISCONSIN ALUMNI RESEARCH FOUNDATION 发明人 PERLMAN, KATO L.;SICINSKI, RAFAL R.;DELUCA, HECTOR F.
分类号 A61K31/59;A61P3/02;A61P17/00;A61P19/10;A61P35/00;A61P43/00;C07C401/00;C07F7/18;(IPC1-7):C07C401/00;C07D309/12;C07D307/20;A61K31/695 主分类号 A61K31/59
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