| 摘要 |
<p>A class of N-substituted piperazine, piperidine and tetrahydropyridine derivatives of formula (I), further substituted at the 4-position by an optionally substituted aryl-alkyl or heteroaryl-alkyl moiety, are selective agonists of 5-HT1-like receptors, being potent agonists of the human 5-HT1Dα receptor subtype relative to the 5-HT1Dβ subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists. In formula (I) Z represents hydrogen, halogen, cyano, nitro, trifluoromethyl, -OR?5, -OCOR5¿, -OCONR5R6, -OCH¿2?CN, -OCH2CONR?5R6, -SR5, -SOR5, SO¿2R5, -SO2NR?5R6, -NR5R6, -NR5COR6, -NR5CO¿2R?6, -NR5SO¿2R?6, -COR5, -CO¿2R?5, -CONR5R6¿, or a group of formula (a), (b), (c) or (d).</p> |
