The present invention relates to variants of Penicillin Binding Proteins (PBP), which proteins are involved in bacterial peptidoglycan biosynthesis. Disclosed are also DNA molecules coding for the said PBP variants, as well as vectors and cells harbouring such DNA molecules. The invention is also related to processes for assaying and designing therapeutically useful compounds which have high affinity to PBP, which processes utilize the said PBP variants.
申请公布号
WO9616082(A1)
申请公布日期
1996.05.30
申请号
WO1995SE00761
申请日期
1995.06.21
申请人
ASTRA AKTIEBOLAG;BALGANESH, TANJORE, SOUNDARARAJAN;TOWN, CHRISTINE, MARY
发明人
BALGANESH, TANJORE, SOUNDARARAJAN;TOWN, CHRISTINE, MARY