摘要 |
Prodn. of 2-aryl-5-perfluoroalkyl-pyrrole-3-carbonitriles of formula (I) comprises reacting a 5-acylamino-4-aryl-2-perfluoroalkyloxazole of formula (II) or a tautomer of (II), with at least 1 molar equiv. of a 2-haloacrylonitrile or 2,-3-dihalopropionitrile in the presence of a base and opt. a solvent. n = 1-8; A = a gp. of formula e.g. (A1): L = H or halo; M,Q = H, halo, CN, NO2,etc.; or adjacent M+Q = OCH2O, OCF2O or CH=CH-CH=CH; R = 1-6C alkyl, 1-6C haloalkyl, COOR1,etc.; R1 = 1-4C alkyl or 1-4C haloalkyl. |