摘要 |
Immunosuppressive cyclolignan derivatives are provided of formula (I) or (II): <CHEM> or <CHEM> in which R<1> is hydrogen, hydroxy, alkoxy; R<2> and R<3> are hydrogen, alkyl, acyl, or together R<2> and R<3> form a group -CHR<4>-; R<4> is hydrogen, alkyl, alkenyl, hydroxyalkyl, (poly)haloalkyl, aryl, acyloxyalkyl, alkoxy, carboxyalkyl, alkoxycarbonyl, carbamoyl; R<5> when present is hydrogen, alkyl, alkenyl, aryl, (poly)haloalkyl, acyl, carbamoyl, or thiocarbamoyl; R<6> is alkyl, hydroxyalkyl, haloalkyl, acyl, acyloxyalkyl, carboxy or alkoxycarbonyl; Ar is 3,4,5-trialkoxyphenyl or 4-hydroxy-3,5-dialkoxyphenyl; and X is nitrogen or oxygen. |