发明名称 |
Amino acid derivatives with improved multi-drug resistance activity |
摘要 |
The present invention relates to compounds that can meintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy. |
申请公布号 |
ZA9509304(B) |
申请公布日期 |
1996.05.29 |
申请号 |
ZA19950009304 |
申请日期 |
1995.11.03 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED. |
发明人 |
ROBERT EDWARD ZELLE;MATTHEW WILLIAM HARDING |
分类号 |
A61K31/16;A61K31/395;C07C237/22;C07D213/38;C07D213/40;C07D213/50;C07D213/81;C07D233/54;C07D233/90;C07D521/00 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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