| 摘要 |
PCT No. PCT/JP94/00326 Sec. 371 Date Nov. 2, 1994 Sec. 102(e) Date Nov. 2, 1994 PCT Filed Feb. 28, 1994 PCT Pub. No. WO94/21836 PCT Pub. Date Sep. 29, 1994.This invention provides a method of inhibiting graft rejection comprising administering a carbostyril derivative and/or its salt to a subject in need of such treatment. The method of this invention enhances the graft survival rate and can be advantageously used in the transplantation of various organs and tissues. This invention also relates to a method for inhibiting IL-1 production comprising administering a carbostyril derivative and/or its salt to a subject in need of such treatment. This method is effective in the prevention and treatment of diseases arising from excess IL-1 production, such as inflammatory diseases, osteoporosis, myelocytic leukemia, etc.
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