发明名称 |
SUBSTITUTED THIAZOLO[3,2-ALFA]AZEPINE DERIVATIVE |
摘要 |
<p>The present invention relates to a substituted thiazoloÄ3,2-aÜazepine derivative having inhibitory activity against angiotensin I converting enzyme and neutral endpeptidase. The above substituted thiazoloÄ3,2-aÜazepine derivative is represented by the following general formula (I): <CHEM> (wherein R1 represents a hydrogen atom or a protecting group of a thiol group; R2 represents a hydrogen atom, a lower alkyl group, an aryl group which may have a substituent, a hetroaryl group which may have a substituent, a lower alkoxyl group or a lower alkylthio group; R3, R4 and R5 may be the same or different from one another and represent each a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a lower alkylthio group or the like, with the proviso that the case wherein all of R3, R4 and R5 are hydrogen atoms are excepted; R6 and R7 may be the same or different from each other and represent each a hydrogen atom or a lower alkyl group; R8 represents a hydrogen atom or a protecting group of a carboxyl group; and m and m are each independently 0 or, 1 or 2).</p> |
申请公布号 |
HU9600679(D0) |
申请公布日期 |
1996.05.28 |
申请号 |
HU19960000679 |
申请日期 |
1995.06.07 |
申请人 |
EISAI CO.,LTD. |
发明人 |
ADACHI,HIDEYUKI;FUKUDA,YOSHIO;KOTAKE,MAKOTO;MATSUOKA,TOSHIYUKI;MATSUSHIMA,TOMOHIRO;MIYAKE,KAZUTOSHI;MIZUNO,MASANORI;NAMIKI,MASAYUKI;OINUMA,HITOSHI;OKITA,MAKOTO;SAITO,MAMORU;SUDA, SHINJI;SUDO, TAKESHI;YONEDA, NAOKI |
分类号 |
A61K38/00;C07D513/04;C07K5/078 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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