Methods and compounds for the preparation of carbacephems

摘要

A chiral process for preparing compounds of the formula: <IMAGE> (V) from a compound of the formula: <IMAGE> (IV) in which the compound formula (IV) is reacted with trimethylsilyl iodide to remove the chiral auxiliary at the 7-position and the carboxy protecting group. The process allows for the retention of the amino and carboxy protecting groups throughout the preparation of Compound IV. Also disclosed are novel intermediates.