发明名称 |
PREPARATION OF HOMOGENEOUS HYDROGEL COPOLYMERS |
摘要 |
A method is provided for the preparation of homogeneous copolymers having a predetermined equilibrium water content (EWC) value formed by the addition polymerization of a mixture of ethylenically unsaturated monomer A and ethylenically unsaturated monomer B, for example, 2-hydroxyethyl methacrylate and hydroxypropyl methacrylate. The method requires determining the EWC values of the hydrogel homopolymer of hydrophilic monomer A (homopolymer A) and the hydrogel homopolymer of hydrophilic monomer B (homopolymer B); determining the relationship of the EWC values of the homogeneous copolymers AB versus the chemical composition of said copolymers AB; selecting the targeted EWC value and determining the chemical composition of copolymer AB having the targeted EWC value; forming a polymerizable mixture of monomer A and monomer B in amounts sufficient to yield copolymer AB having the targeted EWC value; and effect the polymerization reaction to yield copolymer AB characterized by the targeted EWC value. A method is also provided for the preparation of a delivery device including a drug contained in the reservoir of the hydrogel of copolymer AB, said device being characterized by its capability of eluting or releasing the drug through the hydrogel membrane to a delivery environment at a predetermined rate. There is also disclosed a sterilized kit containing a trocar or hypodermic needle/syringe and the aforesaid drug delivery device having a cylindrical shape with a rounded or bullet-like extremity.
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申请公布号 |
CA2059406(C) |
申请公布日期 |
1996.05.28 |
申请号 |
CA19922059406 |
申请日期 |
1992.01.15 |
申请人 |
HYDRO MED SCIENCES, A DIVISION OF NATIONAL PATENT DEVELOPMENT CORPORATION |
发明人 |
KUZMA, PETR;MORO, DANIEL G.;QUANDT, HARRY |
分类号 |
A61K9/00;B29C39/04;B29C41/04;B29K33/04;B29L31/00;C08F220/28;(IPC1-7):A61M37/00;B29C39/08 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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