DERIVATIVES OF 2-MERCAPTOBENZIMIDAZOLE HAVING SELECTIVE ANXYOLYTIC ACTIVITY

摘要

FIELD: medicine. SUBSTANCE: desired products have common formulawhere n= 0,2,3; R is allyl, dialkylamino- or nitrogen-containing heterocycles, Rand Rare the same or different and represent H, lower alkyls and alkoxy. Desired derivatives are prepared by alkylation of 2-mercaptobenzimidazoles with appropriate alkylating agent. The process is followed by treatment thus prepared bases with hydrogen chloride. Said derivatives or their pharmaceutically acceptable salts has anxyolytic action and are low toxic. EFFECT: creates novel derivatives of 2-mercaptobenzimidazole having selective anxyolytic activity.