SUPPRESSION OF PROTEOLYTIC ACTIVITY BY DYSFUNCTIONAL PROTEASE FORMATION
摘要
The present invention provides recombinant vectors comprising polynucleotides encoding defective monomers of HIV (e.g., HIV-1 or HIV-2) protease which are used to interfere with viral maturation. The defective monomers result in the formation of inactive protease heterodimers and thus inhibit the polyprotein processing events that are essential for viral maturation and infectivity.
申请公布号
WO9614863(A1)
申请公布日期
1996.05.23
申请号
WO1995US14481
申请日期
1995.11.06
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;CRAIK, CHARLES, S.;BABE, LILIA, M.;ROSE, JASON, R.
发明人
CRAIK, CHARLES, S.;BABE, LILIA, M.;ROSE, JASON, R.