发明名称 |
METHODS FOR MODULATING TRANSCRIPTION FROM THE AMYLOID beta -PROTEIN PRECURSOR (APP) PROMOTER |
摘要 |
The application concerns methods for modulating transcription from the amyloid beta -protein precursor (APP) promoter. The upstreaam stimulatory factor (USF) is described as being capable of activating transcription from the APP promoter. Also described are USF binding compounds which are capable of down-regulating expression from the APP promoter. Preferred USF binding compounds are the amyloid precursor-like proteins APLP1 and APLP2. The application further concerns a screening assay for determining which candidate USF binding compounds are capable of causing down-regulation of transcription from the APP promoter.
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申请公布号 |
WO9615265(A1) |
申请公布日期 |
1996.05.23 |
申请号 |
WO1995US14416 |
申请日期 |
1995.11.09 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
TANZI, RUDOLPH, E.;KOVACS, DORA, M. |
分类号 |
C12N15/09;A61K38/00;C07K14/47;C12N5/10;C12N15/85;C12Q1/02;(IPC1-7):C12Q1/68;C12N15/66 |
主分类号 |
C12N15/09 |
代理机构 |
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