INTRATHYMIC STEM CELL IMPLANTATION

摘要

Engraftment of grafts in transplant recipients are enhanced by implanting CD34-positive hematopoietic cells obtained from the graft donor in the thymus of the transplant recipient. The methods enhance engraftment of both allogeneic and xenogeneic transplants. Methods are also provided for supplying a gene product of interest in a host mammal by implanting in the thymus of the host CD34-positive hematopoietic progenitor cells which encode the gene product of interest. The CD34-positive hematopoietic cells can be genetically engineered to produce the gene product of interest in the recipient host.