Method for treating anxiety

摘要

The present invention provides the use of a compound wherein X is oxygen or sulphur; R is hydrogen, amino, halogen, -CHO, -NO2, -OR<4>, -SR<4>, -SOR<4>, -SO2R<4>, C3-7-cycloalkyl, C4-8-(cycloalkylalkyl), -Z-C3-7-cycloalkyl, and -Z-C4-8-(cycloalkylalkyl) wherein R<4> is straight or branched C1-15-alkyl, straight or branched C2-15-alkenyl, straight or branched C2-15-alkynyl, each of which is optionally substituted with one or more halogens, -CF3, -CN, phenyl or phenoxy wherein phenyl or phenoxy is optionally substituted with halogen, -CN, C1-4-alkyl, C1-4-alkoxy, -OCF3, -CONH2 or -CSNH2; or R is phenyl or benzyloxycarbonyl, each of which is optionally substituted with halogen, -CN, C1-4-alkyl, C1-4-alkoxy, -OCF3, -CONH2 or -CSNH2; or R is -OR<5>Y, -SR<5>Y, -OR<5>ZY, -SR<5>ZY, -O-R<4>-Z-R<5> or -S-R<4>-Z-R<5> wherein Z is oxygen or sulphur, R5 is straight or branched C1-15-alkynyl, and Y is a 5 or 6 membered heterocyclic group containing one to four N, O or S atom(s) or a combination thereof, which heterocyclic group is optionally substituted at carbon or nitrogen atom(s) with straight or branched C1-6-alkyl, phenyl or benzyl, or which heterocyclic group is optionally fused with a phenyl group; and G is selected from one of the following azabicyclic rings wherein the thiadiazole or oxadiazole ring can be attached at any carbon atom of the azabicyclic ring; R<1> and R<2> may be present at any position, including the point of attachment of the thiadiazole or oxadiazole ring, and independently are hydrogen, straight or branched C1-5-alkyl, straight or branched C2-5 alkenyl, straight or branched C2-5-alkynyl, straight or branched C1-10-alkoxy, straight or branched C1-5-alkyl substituted with -OH, OR<4>, halogen, -NH2 or carboxy; R<3> is H, straight or branched C1-5-alkyl, straight or branched C2-5-alkenyl or straight or branched C2-5-alkynyl; n is 0, 1 or 2; m is 0, 1 or 2; p is 0, 1 or 2; q is 1 or 2; and --- is a single or double bond; or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of anxiety.