A transgenic nonhuman animal model for diabetes

摘要

Disclosed in this invention is a transgenic nonhuman animal comprising recombinant DNA including a promoter of a gene expressed in pancreatic beta -cells and a heat shock protein 70 gene operatively linked downstream to said promoter. Transgenic mice having non-insulin dependent diabetes characterized by a level of 300 mg/dl of glucose in blood were obtained. This transgenic mouse is useful in the fields of research for development of models of diabetes, identification of the mechanism inducing diabetes, development of therapeutic agents and assays for novel medicines.