发明名称 |
ACYLPHENYLGLYCINE DERIVATIVE AND PREVENTIVE AND REMEDY FOR DISEASES CAUSED BY INCREASED COLLAGENASE ACTIVITY CONTAINING SAID COMPOUND AS ACTIVE INGREDIENT |
摘要 |
<p>An acylphenylglycine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, and a preventive and remedy for diseases caused by an increased collagenase activity containing the same as the active ingredient, wherein R<1> represents hydrogen atom, methyl, methylaminomethyl or morpholinomethyl; R<2> represents hydrogen atom, hydroxy, fluorine atom, or C1-C4 linear or branched alkyl; and R<3> represents C1-C4 linear or branched alkyl. The compound (I) and the salt maintains a potent collagenase inhibitor activity in the blood for long after being administered, and are useful as a remedy for various diseases believed to be caused by an increased collagenase activity. <CHEM> <IMAGE></p> |
申请公布号 |
EP0712838(A1) |
申请公布日期 |
1996.05.22 |
申请号 |
EP19940923067 |
申请日期 |
1994.08.03 |
申请人 |
KANEBO LTD. |
发明人 |
HIRAYAMA, RYOICHI;TSUKIDA, TAKAHIRO;YAMAMOTO, MINORU;IKEDA, SHOJI;SAKAMOTO, FUMIO;OBATA, YUJI;MATSUO, KONOMI |
分类号 |
C07C259/06;C07D295/15;(IPC1-7):C07C259/06;A61K31/16 |
主分类号 |
C07C259/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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