| 摘要 |
The invention relates to a process for the preparation of substituted 3-aminobenzonitriles of the formula I in which: R is hydrogen or C1-C12 alkyl, C3-C8 cycloalkyl, COR1, C1-C8 alkoxyalkyl, C1-C6 hydroxyalkyl, C1-C8 aminoalkyl, C1-C8 alkyl-NH(C1-C4 alkyl), C1-C8 alkyl-N(C1-C4 alkyl)2 or substituted or unsubstituted benzyl; and R1 is C1-C8 alkyl, C3-C8 cycloalkyl or phenyl; and which comprises reacting a substituted 3-aminochlorobenzene of the formula II with a cyano-donating reagent Compounds of the formula I are important intermediates in the preparation of benzothiadiazole-7-carboxylic acid, which is obtained by diazotizing and hydrolysing the compounds of the formula I in any desired sequence. |
