| 摘要 |
A process for the production of 6,17 alpha -dimethylpregna-4,6-diene-3,20-dione which comprises isolating 3 beta ,5 alpha , 6 beta -trihydroxy- 6 alpha ,17 alpha - dimethylpregnan-20-one monomethanolate from the solution of a Grignard reaction product of 3 beta ,5 alpha -dihydroxy -17 alpha -methyl-17 beta -carbomethoxyandrostane-6-one and a methylmagnesium halide by solvent displacement with methanol; oxidizing the monomethanolate to the 3,20-dione; dehydrating the said 3,20-dione to the 4-ene-3,20-dione; dehydrating the 4-ene-3,20 dione; removing a 6-methylene-4-ene-3,20-dione byproduct and isolating the desired product.
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