| 摘要 |
The Micronesian marine sponge Phakellia sp. has been found to contain certain key members of the antineoplastic halichondrin/halistatin family. These compounds include halichondrin B, homohalichondrin B, halistatin 1, and halistatin 3. Halistatin 3 is a newly discovered member of this family. It inhibited both the P388 leukemia cell line and selected brain, lung, colon, ovarian, renal, and melanoma type cancer cell lines with ED50/GI50 concentrations on the order of 3x10-5 mu g/ml.
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