发明名称 |
POLYSACCHARIDES HAVING A HIGH IDURONIC ACID CONTENT |
摘要 |
Process for the preparation of polysaccharides having a high iduronic acid content comprising: a) N-deacetylation of the polysaccharide K5 from E. coli or of the heparan sulfate or O-desulfation of heparin or heparan sulfate; b) N-sulfation of the product obtained from the stage a); c) epimerization in presence of the C5 epimerase enzyme; d) sulfation of at least some free hydroxy groups, wherein the stage c) is carried out in a reaction medium constituted by a classical buffer solution formed by HEPES, potassium chloride, EDTA and TRITON X-100 to which a suitable additive is added. |
申请公布号 |
WO9614425(A1) |
申请公布日期 |
1996.05.17 |
申请号 |
WO1995EP04241 |
申请日期 |
1995.10.30 |
申请人 |
INALCO S.P.A.;ZOPPETTI, GIORGIO;ORESTE, PASQUA;CIPOLLETTI, GIOVANNI |
发明人 |
ZOPPETTI, GIORGIO;ORESTE, PASQUA;CIPOLLETTI, GIOVANNI |
分类号 |
A61K31/715;A61P7/02;C08B37/00;C12P19/26 |
主分类号 |
A61K31/715 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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