摘要 |
Antineoplastic cyclolignan derivatives are of formula (I): <IMG> (I) in which Ar is a 3,4,5-trialkoxyphenyl or 4-hydroxy-3,5-dialkoxyphenyl; X is an oxygen, sulphur or nitrogen atom, a methine group =CH- or an alkylmethine group =C(alkyl)-; Y is a hydrogen atom or an alkyl, alkenyl, (poly)haloalkyl, aryl, hydroxy, alkoxy, amino, monoalkylamino, dialkylamino, (poly)haloalkylamino, arylamino, acyl or acetamido group, or the group Y is absent; Z is an alkyl, hydroxyalkyl, acyl, carboxy, alkoxycarbonyl or aryloxycarbonyl group; and the dotted lines indicate one double bond located at position .DELTA.7-8 or .DELTA.8-8'.
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申请人 |
GORDALIZA, MARINA;CASTRO, MARIA ANGELES;SAN FELICIANO, ARTURO;DEL CORRAL, JOSE MARIA MIGUEL;LOPEZ, MARIA LUISA;GRAVALOS, DOLORES G. |
发明人 |
GORDALIZA, MARINA;CASTRO, MARIA ANGELES;SAN FELICIANO, ARTURO;DEL CORRAL, JOSE MARIA MIGUEL;LOPEZ, MARIA LUISA;GRAVALOS, DOLORES G. |