Verbindungen, die Quinazoline und Tetrazolring enthalten, als Antitumorverbindungen
摘要
<p>The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula:- <CHEM> wherein R<1> is (1-4C)alkyl; the quinazoline ring may optionally bear one or two further substituents selected from halogeno, (1-4C)alkyl and (1-4C)alkoxy; R<2> is hydrogen or (1-4C)alkyl; R<3> includes hydrogen and (1-4C)alkyl; and Ar is optionally substituted phenylene or heterocyclene; or a pharmaceutically-acceptable salt or ester thereof.</p>
申请公布号
DE69301048(T2)
申请公布日期
1996.05.15
申请号
DE1993601048T
申请日期
1993.03.09
申请人
ZENECA LTD., LONDON, GB;BRITISH TECHNOLOGY GROUP LTD., LONDON, GB
发明人
PEGG, STEPHEN JOHN, MACCLESFIELD, CHESHIRE SK10 4TG, GB;WARDLEWORTH, JAMES MICHAEL, MACCLESFIELD, CHESHIRE SK10 4TG, GB