Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit

摘要

Systems with a strongly increased saturation solubility (Cs) are obtained by preparing nanosuspensions of medicaments. The saturation solubility of medicaments with low bioavailability may thus be increased. This additional increase of the saturation solubility increases the speed of dissolution beyond what can be achieved by simply enlarging the surface of the medicament. Extremely stable nanosuspensions are obtained by using very low surfactant and stabiliser concentrations. Surfactant-free nanosuspensions may be prepared. Large-scale production of nanosuspensions with a very low content of micrometric particles is made possible by cavitation, with its accompanying advantages. The preparation of nanosuspensions by cavitation was thought to be impossible because the powdered medicament particles were expected to block the more or less 25 mu m wide gap. Alternatively, the nanosuspensions may be prepared by shearing or impact in flow dispersion machines while respecting the above principles of optimum stabilisation or surfactant-free preparation.