New substd. pyridine cpds.

摘要

Substd. pyridine cpds. of formula (I) and their salts and prodrugs, with the exception of 3-hydroxypyridine-2-carboxylic acid-N-(carboxymethyl)amide, are new: Qx = O or S; X = O or S; Y = N or CR<3>; m = 0 or 1; A = (1-4C) alkylene, or CHR<5>; R<5> = a natural alpha amino acid; B = CO2H, CONHCOR"', CONHSOR'", CONHSO2R"', NHSO2CF3, tetrazolyl, imidazolyl or 3-hydroxyisoxazolyl; R"' = aryl, heteroaryl, 3-7C cycloalkyl or opt. monosubstd. U; R<1>, R<2>, R<3> = H, OH, halo, CN, CF3, NO2, COOH, 1-20C alkyl, 3-8C cycloalkyl, Ar, etc.; or R<1>+R<2> or R<2>+R<3> = a chain (CH2)o, in which 1-2 CH2 gps. are opt. replaced by O, S, SO, SO2 or NR' and the chain may contain a C=C double bond; or R<2>+R<3> = 5-6 membered aromatic carbocyclic or heterocyclic ring; Ar = 6-12C aryl; or R<1> + R<2> or R<2> + R<3> = a chain (CH2)o, in which 1-12 CH2 gp. is opt. replaced by O, S, SO, SO2 or NR' and the chain may contain a C-c double bond; or R<2>+R<3> = 5-6 membered aromatic carbocyclic or heterocyclic ring; Ar = 6-12C aryl; R' = H, Ar, 1-8C alkyl, 1-8C alkoxy(1-8C)alkyl, 7-12C aralkoxy(1-8C)alkyl, etc.; R<4> = H; o = 3-5; x = 0-3;T = 1-6C alkyl; U = 1-4C alkyl.