Cyclic synthetic peptides and mixtures thereof for detecting hiv antibodies and producing vaccines

摘要

There is provided cyclic peptides of the general formula wherein x represents the amino terminus, one amino acid or amino acid sequence starting with amino acid 604 and going back as far as amino acid 586 (gp41-HIV-1); and y represents the carboxy terminus, an amino acid or amino acid sequence starting with amino acid 612 and extending up to amino acid 629 (gp41-HIV-1). There is also provided peptides of the general formula wherein x<1> represents the amino terminus, one amino acid or amino acid sequence starting with amino acid 596 and going back as far as amino acid 578 (gp42-HIV-2); and y<1> represents the carboxy terminus, an amino acid or amino acid sequence starting with amino acid 604 and extending up to amino acid 613 (gp42-HIV-2). These cyclic peptides alone or in admixture with certain linear peptides are particularly useful in detecting antibodies.