发明名称 |
Aminoxyl-containing radical spin labeling in polymers and copolymers |
摘要 |
Aminoxyl-containing radical is provided in polymers and copolymers by replacing a hydroxyl moiety in a carboxyl group at a chain end of a starting material biodegradable polymer or copolymer with imino or oxy linked to aminoxyl-containing radical to form an amide linkage or an oxycarbonyl linkage at the chain end of biocompatible polymers or copolymers to the aminoxyl-containing radical. Preferred starting material polymers and copolymers are prepared from the hydroxy alkyl carboxylic acid monomers glycolic acid and lactic acid. Preferred aminoxyl-containing radical is 2,2,6,6-tetramethylpiperidine-1-oxy. Product polymers are useful for aminoxyl-containing radical treatment of tumors, and to increase the efficiency of chemotherapy and ionizing radiation therapy of tumors and for the reconstruction of injured, diseased, or aged human blood vessels.
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申请公布号 |
US5516881(A) |
申请公布日期 |
1996.05.14 |
申请号 |
US19940288601 |
申请日期 |
1994.08.10 |
申请人 |
CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
LEE, KEUN-HO;CHU, CHIH-CHANG;FREED, JACK H. |
分类号 |
C08G63/91;(IPC1-7):C08G73/10 |
主分类号 |
C08G63/91 |
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地址 |
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