发明名称 |
N- and C-terminal truncation and deletion mutants of human interleukin-3 |
摘要 |
Biologically active deletion and substitution mutants of hIL-3 are provided. Preferred mutants are those having one or more deletions at the N-terminus (amino acids 1-14) and/or the C-terminus (amino acids 116-133, 120-130 and/or 130-133). Preferred substitution mutants include Cys16->Ala16 and/or Cys84->Ala84, Glu50->Lys50 and Lys79->Glu79. These mutants can be used to formulate pharmaceutical compositions. Also disclosed are antibodies directed against specific epitopes localized between amino acids 29 and 54.
|
申请公布号 |
US5516512(A) |
申请公布日期 |
1996.05.14 |
申请号 |
US19930150331 |
申请日期 |
1993.11.08 |
申请人 |
GIST-BROCADES, N.V. |
发明人 |
DORSSERS, LAMBERTUS C. J.;VAN LEEN, ROBERT W. |
分类号 |
C07K14/54;C07K16/24;(IPC1-7):A61K38/20 |
主分类号 |
C07K14/54 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|