| 摘要 |
O-Aryl methyl N-acyl or N-thioacyl hydroxylamine derivs. of formula ArCH2ON(R1)C(=X)R2 (I), their enantiomers and diastereoisomers are new. X = O or S; R1 = H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, or arylalkyl; R2 = R21 or R22; R21 = H or alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkylalkyl all of which may be substd.; R22 = alkylamino, cycloalkylamino, or cycloalkylalkylamino which may be substd. on the (cyclo)alkyl gps.; Ar = naphthyl, indolyl, benzofuranyl, or benzothiophenyl, all of which may be partially or fully hydrogenated. alkyl, alkoxy = 1-6C, alkenyl, alkynyl = 2-6C, cycloalkyl = 3-8C, and opt. substits. on these may be halo, alkyl or alkoxy. Opt. substits. on Ar gps. are one or more gps. R; R = halo, OH, Ra, -CH2Ra, -O-Ra, -CO-Ra or -O-CO-Ra; Ra = opt. substd. alkyl, alkenyl, alkynyl, opt. substd. cycloalkyl, opt. substd. cycloalkylalkyl, opt. substd. aryl or opt. substd. aralkyl; the substits. on aryl and aralkyl gps. may be halo, alkyl, alkoxy, OH and/or haloalkyl. |
