| 发明名称 |
BISARYLCARBINOL CINNAMIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS |
| 摘要 |
Compounds having the formula (I): R<1>R<2>C(OR<3>)-Ar<1>-X-Ar<2>-C(Ar<3>)=CHCO2H are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
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| 申请公布号 |
WO9613491(A1) |
申请公布日期 |
1996.05.09 |
| 申请号 |
WO1995CA00607 |
申请日期 |
1995.10.25 |
| 申请人 |
MERCK FROSST CANADA INC.;DELORME, DANIEL;DUCHARME, YVES;FRIESEN, RICHARD;GRIMM, ERICH, L.;LEPINE, CAROLE |
发明人 |
DELORME, DANIEL;DUCHARME, YVES;FRIESEN, RICHARD;GRIMM, ERICH, L.;LEPINE, CAROLE |
| 分类号 |
C07D233/64;A61K31/19;A61K31/34;A61K31/341;A61K31/38;A61K31/381;A61K31/40;A61K31/425;A61K31/426;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/443;A61P11/08;A61P27/02;A61P29/00;A61P43/00;C07C59/66;C07C205/59;C07C317/44;C07C317/46;C07C323/50;C07C323/62;C07D207/32;C07D207/33;C07D207/337;C07D213/55;C07D213/61;C07D213/64;C07D213/70;C07D213/71;C07D277/20;C07D277/24;C07D277/30;C07D307/54;C07D333/28;C07D405/12;C07D417/12;C07D521/00;(IPC1-7):C07D277/24;C07D307/46;C07C323/20 |
主分类号 |
C07D233/64 |
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