PROTEIN KINASE INHIBITORS FOR TREATMENT OF NEUROLOGICAL DISORDERS
摘要
The invention features novel derivatives of K-252a e.g. (II-4) as well as novel bis-N-substituted derivatives of staurosporine of Formula (I). The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a. In the formula (I): ¢Stau! -N(CH3)-W-N(CH3)-¢Stau!, ¢Stau! represents a residue of formula (a) and W represents a radical of the formula: -C(=Y)-NH-W'-NH-C(=Y)- where W' is a hydrocarbylene radical of 2-20 carbon atoms and Y is O or S. In formula (II-4) R1, R2, Z1, and Z2 are each H; X is CH2OH; and R is OCH3.
申请公布号
CA2203767(A1)
申请公布日期
1996.05.09
申请号
CA19952203767
申请日期
1995.10.04
申请人
KYOWA HAKKO KOGYO CO., LTD.;CEPHALON, INC.
发明人
NEFF, NICOLA;ROBERTS-LEWIS, JILL;SAITO, HIROMITSU;MURAKATA, CHIKARA;MATSUDA, YUZURU;KANAI, FUMIHIKO;KANEKO, MASAMI;GLICKSMAN, MARCIE;LEWIS, MICHAEL E.;KAUER, JAMES C.