NOVEL FAMILY OF PROTEASE INHIBITORS, AND OTHER BIOLOGIC ACTIVE SUBSTANCES

摘要

The invention relates to novel protease-inhibitors which are obtainable from leeches. It also relates to uses thereof, for instance as a medicament, thus pharmaceutical preparations are provided, as are derivatives, mutants, genes encoding, vectors comprising and cells provided with such genes and/or vectors. In particular the invention relates to a family of proteinaceous protease inhibitors having a molecular weight of about 5.5kD and the following primary sequences DDNCGGKVCSKGQLCHDGHCECTPIRCLIFCPNGFAVDENGCELPCSCKHQ,DDDCGGQVCSKGQLCVDGQCKCTPIRC RIYCPKGFEVDENGCELPCTCLQ,DGNCGGQVCSKGQLCVDGQCKCTPIRCRIYCPKGFEVDENGCELPCTCLQ. This invention also relates to HIV-inhibitors and other therapeutically interesting, low molecular weight, and low antigenic substances from leeches.