| 摘要 |
Reservoir-type microcapsules (M) contg. pharmaceutical and/or nutritional active ingredient (I) (excluding acetylsalicylic acid) and intended for oral use consist of particles of (I) each coated with a compsn. contg. at least one each of film-forming polymer (P1); N-contg. polymer (P2); plasticiser (P) and surfactant and/or lubricant (S). M have size 50-1000 (esp. 100-500) microns and remain in small intestine for at least 5 (pref. 8-24) hrs. to allow release of (I) during at least part of this time. P1 is insol. in gastrointestinal fluid, is 50-90 (pref. 50-80) wt.% (dry basis) of coating compsn. and is water-insol. cellulose deriv. P2, present at 2-25 (pref. 5-15) wt.% of the compsn. is a polyacrylamide, poly-N-vinylamide or poly-N-vinyl lactam (esp. polyacrylamide and/or PVP). (P) is 2-20 (pref. 4-15) wt.% of compsn. and is a glycerol ester, phthalate, citrate, sebacate, cetyl ester, castor oil (best), salicylic acid and/or cutin. (S) is 2-20 (pref. 4-15) wt.% of compsn. and is (a) anionic surfactant, nonionic surfactant and/or a lubricant. Also new are galenical formulations, pref. tablets, powders, or capsules, contg. M. |
