PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS

摘要

The invention relates to Pyridopyrimidones, Quinolines and fused N-heterocyclic compounds of formula (I) wherein Z is a group of the formula (a) or (b) in which X<1> is N or C-R<1>, X<2> is N or C-R<9>, X<3> is N or C-R<2>, R<1> is lower alkyl, R<2> is hydrogen, lower alkyl, etc., R<9> is hydrogen or lower alkyl, R<3> is halogen, etc., R<4> is halogen, etc., R<5> is a group of formula (c), etc., A is lower alkylene, and Y is O, etc., and pharmaceutically acceptable salts thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods of using the same therapeutically in the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.