发明名称 |
Salts of nefazodone having improved dissolution rates |
摘要 |
The L-malate, L-tartrate and methane sulfonate salts of nefazodone showed significantly higher intrinsic dissolution in water and THAM buffer compared to other salts of nefazodone. The faster dissolution rates of these salts at higher pH's may suggests better dissolution and absorption in the intestine, and improved bioavailability for oral formulations. <IMAGE> |
申请公布号 |
AU3458395(A) |
申请公布日期 |
1996.05.09 |
申请号 |
AU19950034583 |
申请日期 |
1995.11.01 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
HEMANT N. JOSHI;TERRY D. WILSON;JATIN M. PATEL |
分类号 |
A61K31/495;A61K47/12;A61K47/20;A61P25/24;A61P25/26;C07D249/12 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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