| 摘要 |
Disclosed are amidinophenol derivatives of the formula (I) and acid-addition salts thereof (in which R1 and R2 are alkyl, alkoxy, acyl, halogen, nitro, benzoyl, COOR4; A is bond, alkylene, group of the formula (II); R3 is group of the formula (III), (IV)) <IMAGE> (I) <IMAGE> (II) <IMAGE> (III) <IMAGE> (IV) Compounds of the formula (I) have inhibitory activities on phospholipase A2 and proteases (especially trypsin), and are useful for the prevention and/or the treatment of inflammatory diseases, allergic diseases, disseminated intravascular coagulation, pancreatitis, severity in pancreatitis and multiple organ failure.
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