发明名称 |
Conotoxin peptides |
摘要 |
The invention is directed to A-lineage conotoxin peptides, which are conotoxin peptides that have strong homology in the signal sequence and the 3'-untranslated region of the genes coding for these peptides to the sequences in the alpha -conotoxin peptides. The A-lineage conotoxin peptides include the alpha -conotoxin peptides, the alpha -conotoxin-like peptides and the kappa -conotoxin peptides, described further below. The alpha -conotoxin-peptides generally share a "core" sequence motif. This core sequence is termed the alpha 3/5 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:1). The alpha -conotoxin-like peptides generally share a core sequence termed the alpha 4/7 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:2). The kappa -conotoxin peptides generally have a core sequence termed the kappa 7/2/1/3 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Cys-Xaa-Cys-Xaa-Xaa-Xaa-Cys (SEQ ID NO:3).
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申请公布号 |
US5514774(A) |
申请公布日期 |
1996.05.07 |
申请号 |
US19930137800 |
申请日期 |
1993.10.19 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
OLIVERA, BALDOMERO M.;CRUZ, LOURDES J.;HILLYARD, DAVID R.;MCINTOSH, J. MICHAEL;SANTOS, AMEURFINA D. |
分类号 |
C12N15/09;A61K38/00;A61K39/00;C07K7/06;C07K7/08;C07K14/435;C12N15/12;(IPC1-7):C07K7/00;A61K38/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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