| 摘要 |
Substd. aminocycloalkanes of formula (I), their isomers and, if basic gps. are present, salts with (in)organic acids are new: m = 0 or 1; X = 0, 5 or -MR5; R1 = phenyl with 1-3 substits. (i.e. 1-3 (1-4C alkyl; one phenyl; 1 or 2 OH; halo; benzyloxy; allyloxy or propargyloxy; 1-3 1-4C alkoxy(opt. substd. by NR6R7); one HCO or one up to 4C acetal gp.), or R1 furyl, thienyl or pyrimidinyl (all opt. substd. by 1-3C alkyl and/or alkoxy), or pyridyl or naphthyl; R2a-R2h = H or 1-3C alkyl or alkenyl; R3 = 1-5C alkyl, alkenyl or alkynyl, phenyl, cyclohexyl or cyclohexylmethyl; R4 = 3-19C alkyl or alkenyl (opt. interrupted by O or S, with 1-3 double bonds for alkenyl), phenyl substd. 1-4C alkyl or 2-4C alkenyl (opt. ring substd. by 1-3C alkyl or alkoxy), phenyl (0pt. substd. by 1 or 2 of 1-3C alkyl or alkoxy, or halo); cyclohexyl, cyclohexyl, (1-4C)alkyl or cyclohexyl(2-4C)alkenyl, biphenyl or (opt. substd. by 1-3C alkyl) furyl, thienyl or pyridyl; R5 = phenyl or p-toluenesulphonyl; R6 and R7 = H, phenyl, 1-6C alkyl (opt. substd. by phenyl) or together they complete piperidino, morpholino or pyrrolidino.
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| 申请人 |
DR. KARL THOMAE GMBH, 88400 BIBERACH, DE |
发明人 |
MAIER, ROLAND, DIPL.-CHEM. DR., 88400 BIBERACH, DE;MUELLER, PETER, DIPL.-CHEM. DR., 88441 MITTELBIBERACH, DE;WOITUN, EBERHARD, DIPL.-CHEM. DR., 88400 BIBERACH, DE;HURNAUS, RUDOLF, DIPL.-CHEM. DR., 88400 BIBERACH, DE;MARK, MICHAEL, DR., 88400 BIBERACH, DE;EISELE, BERNHARD, DIPL.-CHEM. DR., 88400 BIBERACH, DE;BUDZINSKI, RALPH-MICHAEL, DIPL.-BIOL. DR., 88400 BIBERACH, DE |
