发明名称 HYDROXYETHYL AMINIMIDES
摘要 This invention relates to a class of aminimides structurally characterized as an acyl nitrogen-nitrogen ylide such that the acyl moiety possesses the structural diversity element G, the quaternary nitrogen possesses structural diversity elements E and F, and the quaternary nitrogen is bonded to a hydroxyethyl substituent, which in turn is bonded to an aminomethylene moiety that possesses structural diversity elements A and B from the amino group and diversity element C from the methylene substituent, as shown in chemical formula (I), wherein structural diversity elements A, B, C, D, E, F and G are chosen from the set of elements consisting of substituted and unsubstituted as well as branched and straight chain alkyl, aryl, alkaryl, aralkyl, carbocyclic, heterocyclic, hydrogen, amino acid, peptide, polypeptide, protein, depsipeptide, carbohydrate derivatives, nucleotide derivatives, oligonucleotide derivatives, naturally occurring or synthetic organic structural motifs, reporter elements, organic moieties containing at least one polymerizable group, macromolecular component, resin, silicate, other surface and particle support, the diversity elements can be the same, can be different, and can also be connected to form a ringed to several ringed species.
申请公布号 WO9612482(A1) 申请公布日期 1996.05.02
申请号 WO1995US12861 申请日期 1995.10.18
申请人 ARQULE, INC. 发明人 HOGAN, JOSEPH, C., JR.;CASEBIER, DAVID;FURTH, PAUL, S.;GALLION, STEVE;KAPLAN, ALAN
分类号 A61K38/00;A61K31/16;A61K31/66;A61P43/00;C07C243/24;C07C243/40;C07C271/20;C07D213/81;C07D213/82;C07D307/20;C07D309/12;(IPC1-7):A61K31/15 主分类号 A61K38/00
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