| 发明名称 |
CYCLOSPORIN DERIVATIVE WITH MODIFIED 8-AMINO ACID |
| 摘要 |
A new cyclosporin derivative with incorporated "8-(3-fluoro-D-alanine)" or "8-(2-deutero-3-fluoro-D-alanine)" has been isolated from the fermentation broth of incubating Tolypocladium inflatum MF5080 (NRRL 8044) with 3-fluoro-D-alanine or its 2-deuterated isomer respectively. The modified cyclosporins exhibit immunosuppressive properties.
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| 申请公布号 |
CA1338319(C) |
申请公布日期 |
1996.05.07 |
| 申请号 |
CA19880585752 |
申请日期 |
1988.12.13 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
PATCHETT, ARTHUR A.;WHITE, RAYMOND F.;GOEGELMAN, ROBERT T. |
| 分类号 |
A61K38/00;C07K7/64;(IPC1-7):C12P21/04;A61K38/13 |
主分类号 |
A61K38/00 |
| 代理机构 |
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