| 摘要 |
<p>The present invention relates to synthetic immunomodulatory polypeptides which comprise a cyclised fragment of human IgG heavy chain polypeptide, derivative or analog thereof. A preferred immunomodulatory cyclic polypeptide of the present invention has formula (I). The invention provides synthetic immunomodulatory polypeptides capable of enhancing antibody production by acting on stimulated B cells, and such polypeptides in the form of a construct with an antigen or fragment thereof capable of down regulating undesirable immune responses.</p> |
