| 摘要 |
<p>Methods of treating an individual with Alzheimer's disease by administering to the patient a therapeutically effective dose of a compound which interferes with the interaction between Alzheimer β-protein and Apolipoprotein E4 or α1-antichymotrypsin, thereby suppressing the formation of Alzheimer β-protein filaments and the neurotoxic effects of these filaments. The present invention also refers to methods of screening for compounds which are effective drugs for treating Alzheimer's disease. These methods comprise screening for compounds which suppress the formation of Alzheimer β-protein filaments in the presence of promoting factors and which suppress the neurotoxic effects of these filaments formed in the presence of promoting factors.</p> |
