NOVEL AND IMPROVED AMINOGLYCOSIDE FORMULATION FOR AEROSOLIZATION

摘要

An aminoglycoside formulation for delivery by aerosolization. The concentrated aminoglycoside formulation containing an efficacious amount of aminoglycoside able to inhibit 95-100 % of susceptible bacteria. Aminoglycoside is formulated in 5 ml solution of a quater normal saline having pH between 5.5 and 6.5. The method for treatment of endobronchial infections by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 mu , produced by a jet or ultrasonic nebulizer.