发明名称 New N-cyclohexyl-N-phenyl-urea cholesterol biosynthesis inhibitors
摘要 N1-Cyclohexyl-N3-phenyl-urea or thiourea derivs. of formula (I) and their acid addn. salts are new: X = O or S; R1 = t-Bu or Ph (opt. mono- or disubstd. by 1-3C alkyl, OH or 1-3C alkoxy (opt. substd. in 2- or 3-position by di- 1-3C alkylamino, pyrrolidino, piperidino or hexamethyleneimino)); R2 = H, Me or Et; R3 = 1-3C alkyl; R4 = 1-12C alkyl, 3-12C mono- or polyunsatd. alkenyl or alkynyl opt. monosubstd. by Ph (substd. by R5 and R6), 7-12C cycloalkyl or Ph substd. by R5 and R6; R5, R6 = H, F, Cl, Br, CF3, 1-4C alkyl or alkoxy; or Ph+R5+R6 = naphthyl.
申请公布号 DE4438021(A1) 申请公布日期 1996.05.02
申请号 DE19944438021 申请日期 1994.10.25
申请人 DR. KARL THOMAE GMBH, 88400 BIBERACH, DE 发明人 HURNAUS, RUDOLF, DIPL.-CHEM. DR., 88400 BIBERACH, DE;MAIER, ROLAND, DIPL.-CHEM. DR., 88400 BIBERACH, DE;MUELLER, PETER, DIPL.-CHEM. DR., 88441 MITTELBIBERACH, DE;WOITUN, EBERHARD, DIPL.-CHEM. DR., 88400 BIBERACH, DE;MARK, MICHAEL, DR., 88400 BIBERACH, DE;EISELE, BERNHARD, DIPL.-CHEM. DR., 88400 BIBERACH, DE;BUDZINSKI, RALPH-MICHAEL, DIPL.-BIOL. DR., 88400 BIBERACH, DE;HALLERMAYER, GERHARD, DIPL.-CHEM. DR., 88437 MASELHEIM, DE
分类号 C07C275/28;(IPC1-7):C07C275/28;A61K31/17;C07C273/18;C07C275/26;C07C275/30;C07C275/34;C07C335/16;C07D295/135 主分类号 C07C275/28
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