| 摘要 |
<p>A 1,2-ethanediol derivative represented by general formula (I) or a salt thereof (wherein R1 represents optionally substituted phenyl, naphthyl, indanyl, indenyl, tetrahydronaphthyl or heterocyclic group; R2 represents hydrogen, alkyl or a hydroxyl-protecting group; R3 represents hydrogen or lower alkyl; nR4s and nR5s represent each independently hydrogen or lower alkyl; R6 represents optionally substituted amino or a nitrogenous heterocyclic group, or ammonio; and n represents an integer of 0 to 6). The compound has an excellent effect of potentiating the nerve growth factor acivity and is useful as a remedy for various diseases caused by central or peripheral nervous system degeneration, such as senile dementia of Alzheimer type, Huntington's chorea, various types of neuropathy and Riley-Day syndrome, traumatic neurosis and amyotrophic lateral sclerosis (ALS).</p> |
