摘要 |
<p>Chiral N-protected 2-ferrocenyl-substituted 1,3-oxazolidin-5-ones, which may be prepared by reaction of an α-amino acid or salt thereof with ferrocene carboxaldehyde or a derivative thereof and cyclisation of the resulting Schiff's base, may be stereoselectively substituted at the α-carbon atom of the α-amino acids to yield further chiral N-protected 2-ferrocenyl-substituted 1,3-oxazolidin-5-ones which in turn may be cleaved to yield substantially enantiomerically pure α-substituted α-amino acids.</p> |