| 发明名称 |
PRODUCTION AND USE OF HUMAN AND PLANT METHYLTRANSFERASES |
| 摘要 |
An isolated recombinant human L-isoaspartyl/D-aspartyl protein methyltransferase is obtained by overexpression of cDNA coding for isozyme II in an E. coli strain, and a cDNA clone of the wheat enzyme and a purified enzyme from wheat are obtained. These enzymes are useful in treatment of medical conditions and diagnosis of disease associated with an increase in L-isoaspartyl/D-aspartyl residues of polypeptides in a tissue.
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| 申请公布号 |
WO9612797(A1) |
申请公布日期 |
1996.05.02 |
| 申请号 |
WO1995US13691 |
申请日期 |
1995.10.19 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MACLAREN, DUNCAN, C.;MUDGETT, MARY, BETH;CLARKE, STEVEN |
| 分类号 |
C12N15/09;A61K8/00;A61K8/30;A61K8/66;A61K31/70;A61K38/00;A61K38/45;A61P9/00;A61P13/02;A61P15/00;A61P17/00;A61P25/28;A61P27/02;A61Q5/00;C12N9/10;C12N15/00;C12Q1/48;C12R1/19;C12R1/91;(IPC1-7):C12N9/10;C12N15/63;C12P21/06;A61K38/51 |
主分类号 |
C12N15/09 |
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