POTENTIATOR FOR NERVE GROWTH FACTOR ACTIVITY CONTAINING 1,2-ETHANEDIOL DERIVATIVE OR SALT THEREOF

摘要

A 1,2-ethanediol derivative represented by general formula (I) or a salt thereof (wherein R<1> represents optionally substituted phenyl, naphthyl, indanyl, indenyl, tetrahydronaphthyl or heterocyclic group; R<2> represents hydrogen, alkyl or a hydroxyl-protecting group; R<3> represents hydrogen or lower alkyl; nR<4>s and nR<5>s represent each independently hydrogen or lower alkyl; R<6> represents optionally substituted amino or a nitrogenous heterocyclic group, or ammonio; and n represents an integer of 0 to 6). The compound has an excellent effect of potentiating the nerve growth factor acivity and is useful as a remedy for various diseases caused by central or peripheral nervous system degeneration, such as senile dementia of Alzheimer type, Huntington's chorea, various types of neuropathy and Riley-Day syndrome, traumatic neurosis and amyotrophic lateral sclerosis (ALS).