METHOD FOR INCREASING THE RESISTANCE OF NEURAL CELLS TO beta -AMYLOID PEPTIDE TOXICITY

摘要

Neural cells which express P75 nerve growth factor receptor (p75<NTR>) and which have a low resistance to beta -amyloid peptide toxicity are treated with a binding agent that binds with p75<NTR>. The resulting neural cells display an increased resistance to beta -amyloid peptide toxicity. Mutant and transfected neural cells are also disclosed in which the ability to express p75<NTR> has been removed with a resultant increase in resistance to beta -amyloid peptide toxicity.